pentobarbital will reduce the extent or influence of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Pitolisant publicity is lessened by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will reduce the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 m